複素環化合物の研究(第18報)Imidazo[1,2-c]-およびPyrimido[1,2-c]pyrimidine誘導体の合成
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概要
- 論文の詳細を見る
2,4-Dichloro- (Ia, b) or 4,6-dichloropyrimidine (II) was treated with aminoalcohols to afford the 4-substituted compounds. When these compounds were treated with thionyl chloride in tetrahydrofuran, cyclized compounds (Va, b, VIb, XIa, b, XIIb, XVa, b, XVII, XIX, and XXI) were obtained. In this reaction, some of the compounds (VIb and XIIb) were substituted by chlorine atom at the 5-position of pyrimidine ring. By the reaction of compound XXI with alkaline solution under a mild condition, ring opening of the pyrimidine occurred to give imidazolidine derivatives (XXII and XXIII). The compounds Ia, b or II was treated with aminoacetal to afford 4-(2,2-diethoxyethylamino) compounds, which were converted to imidazo[1,2-c]pyrimidines (XXVIIa, b and XXXII) by the reaction with 6 N hydrochloric acid followed by cone. sulfuric acid. In this case, ring opened compound (XXXIII) was obtained as a minor product.
- 公益社団法人日本薬学会の論文
- 1974-12-25
著者
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梁井 光二
Faculty Of Pharmaceutical Sciences Nagasaki University
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武田 成子
Faculty of Pharmaceutical Sciences, Nagasaki University
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梁井 光二
長崎大学薬学部
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武田 成子
長崎大学薬学部
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馬場 強三
長崎大学薬学部
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北川 浩一
長崎大学薬学部
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武田 成子
Faculty Of Pharmaceutical Sciences Nagasaki University
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梁井 光二
Faculty of Pharmaceutical Sciences, Nagasaki University
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