Studies on the Pyridazine Derivatives. XIV. Synthesis and Reaction of Pyrimido [4,5-c] pyridazines
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概要
- 論文の詳細を見る
New pyrimido [4,5-c] pyridazines were synthesized by cyclization of 3-amino-4-carbamoylpyridazines (IV, VII) and 3-chloro-4-ethoxycarbonylpyridazine (II). When 3-chloro-5-hydroxypyrimido [4,5-c] pyridazine (XVI) was treated with phosphorous oxychloride and N, N-dimethylaniline, 1,4-dihydro-3,5-dichloro-4-(4'-N, N-dimethylaminophenyl) pyrimido-[4,5-c] pyridazine (XX) was obtained, the structure was established by nuclear magnetic resonance spectra of dechlorination and hydrolysis products. Amination of XX affored 3-chloro-5-amino compounds.
- 公益社団法人日本薬学会の論文
- 1971-09-25
著者
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木下 敏夫
Faculty of Pharmaceutical Sciences, Nagasaki University
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梁井 光二
Faculty Of Pharmaceutical Sciences Nagasaki University
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渡辺 熙
Faculty Of Pharmaceutical Sciences Nagasaki University
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岩崎 晋
Faculty of Pharmaceutical Sciences, Nagasaki University
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岩崎 晋
Faculty Of Pharmaceutical Sciences Nagasaki University
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梁井 光二
Faculty of Pharmaceutical Sciences, Nagasaki University
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