Pyridazine誘導体の合成研究(第7報) : 3,6-Dialkoxypyridazine 1-Oxide類とハロゲン化アルキルおよびハロゲン化アシルとの反応 その2
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 3,6-dimethoxy-4-nitropyridazine 1-oxide (I) with acetyl or benzoyl chloride gives 1-acetoxy (or benzoyloxy)-3-methoxy-4-chloro-6 (1H)-pyridazinone (II or IV). It was found that in this reaction, 3,6-dimethoxy-4-chloropyridazine 1-oxide (VI) is formed as an intermediate which reacts with acetyl chloride to form II. Oxidation of V with acetic acid and hydrogen peroxide gave VI, VIII, and IX. Methoxylation of VI with sodium methoxide gave a product which agree with VII obtained by methoxylation of I. This fact proved that VI is 3,6-dimethoxy-4-chloropyridazine 1-oxide. Separation of VIII by thin-layer chromatography and measurement of its ultraviolet spectrum showed that it is 3,6-dimethoxy-5-chloropyridazine 1-oxide, an isomer of VI.
- 公益社団法人日本薬学会の論文
- 1966-04-25
著者
-
梁井 光二
Faculty Of Pharmaceutical Sciences Nagasaki University
-
梁井 光二
長崎大学薬学部
-
木下 敏夫
長崎大学薬学部
-
梁井 光二
Faculty of Pharmaceutical Sciences, Nagasaki University
関連論文
- Studies on the Heterocyclic Compounds. XXI. A New Alkylation of Pyridazines with Nitromethane and Nitroethane
- Studies on the Heterocyclic Compounds. XX. The Reaction of 4-Cyano-3,6-dichloropyridazine with Amines
- Studies on the Heterocyclic Compounds. XIX. A Novel Ring Isomerization of 3-Ylideneaminoimidazo [4,5-c] pyridazines
- 複素環化合物の研究(第18報)Imidazo[1,2-c]-およびPyrimido[1,2-c]pyrimidine誘導体の合成
- Studies on the Pyridazine Derivatives. XVII. Structural Studies on the Product of 3-Hydrazino-4-aminopyridazine with Formic Acid (A Novel Ring Isomerization)
- Studies on the Pyridazine Derivatives. XVI. Reaction of 3-Alkoxy-4-nitro-(and 4,6-dinitro) pyridazine 1-Oxides with Amines
- Studies on the Pyridazine Derivatives. XIV. Synthesis and Reaction of Pyrimido [4,5-c] pyridazines
- Studies on the Synthesis of Pyridazine Derivatives. XIII. Synthesis of Imidazo-[4,5-d]- and v-Triazolo[4,5-d]pyridazine Derivatives and Reaction of 4-Alkoxy-v-triazolo[4,5-d]pyridazines with Various Amines
- Studies on the Synthesis of Pyridazine Derivatives. XII. Synthesis of 4,5-Diaminopyridazine Derivatives
- Studies on the Synthesis of Pyridazine Derivatives. X. Reaction of 3,6-Dimethoxy-4-nitropyridazine 1-Oxide with Alkyl Halides
- Studies on the Synthesis of Pyridazine Derivatives. IX. Synthesis of 10H-Pyridazino (3,2-b) quinazolin-10-one and Its Derivatives. (3)
- Pyridazine誘導体の合成研究(第8報) : Alkoxypyridazine N-Oxide類のエーテル交換反応について
- 3,6-Dimethoxy-4-nitropyridazine 1-Oxideとハロゲン化アルキルとの反応
- Pyridazine誘導体の合成研究(第7報) : 3,6-Dialkoxypyridazine 1-Oxide類とハロゲン化アルキルおよびハロゲン化アシルとの反応 その2
- Pyridazine誘導体の合成研究(第6報) : 3,6-Dialkoxypyridazine 1-Oxide類とハロゲン化アルキルおよびハロゲン化アシルとの反応 その1
- Pyridazine誘導体の合成研究(第5報) : 10H-Pyridazino[3,2-b]quinazolin-10-oneおよびその誘導体の合成 その2
- Studies on the Synthesis of Pyridazine Derivatives. XI. Reaction of 3,6-Dialkoxypyridazine 1-Oxide with Alkylhalides, Haloketones and Haloacid Esters, and Decomposition of Reaction Products
- 安定イオウイリドの研究(第9報)Dimethylsulfonium AcetylcarbamoylmethylideとIsoquinoline 2-Oxideとの反応
- Triphenylphosphonium Allylide類と塩基との反応
- 安定イオウイリドの研究(第6報)Dimethylsulfonium AcetylmethoxycarbonylmethylideおよびDimethylsulfonium DiacetylmethylideとIsoquinoline 2-Oxideとの反応
- 安定イオウイリドの研究(第1報)Dimethyloxo-およびDimethylsulfonium BenzoylmethylideとAromatic Amine N-Oxide類との反応