Pyridazine誘導体の合成研究(第6報) : 3,6-Dialkoxypyridazine 1-Oxide類とハロゲン化アルキルおよびハロゲン化アシルとの反応 その1
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概要
- 論文の詳細を見る
Twenty-four kinds of pyridazinone derivatives (II) were synthesized by the application of methyl or ethyl iodide, acetyl, benzoyl, or benzyl chloride, or 2-bromoacetophenone to 3,6-dimethoxy-, 3,6-diethoxy-, 3,6-dimethoxy-4-methyl-, and 3,6-diethoxy-4-methylpyridazine 1-oxides (I), and infrared and ultraviolet spectra of II were measured. Reactivity of these reagents decreased in the order of acetyl chloride, benzoyl chloride, methyl and ethyl iodide, and benzyl chloride. 1-Phenacy1oxy-3-alkoxy-6(1H)-pyridazi-nones (II_<13〜16>) were found to undergo decomposition by heat, alcohol, acid, and alkali to form 3-alkoxy-6(1H)-pyridazinones (IIIa, b, c) and phenylglyoxal (IV).
- 公益社団法人日本薬学会の論文
- 1966-02-25
著者
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梁井 光二
Faculty Of Pharmaceutical Sciences Nagasaki University
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梁井 光二
長崎大学薬学部
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木下 敏夫
長崎大学薬学部
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山口 昌昭
長崎大学薬学部
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山口 昌昭
Faculty Of Pharmaceutical Sciences Nagasaki University
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梁井 光二
Faculty of Pharmaceutical Sciences, Nagasaki University
関連論文
- Studies on the Heterocyclic Compounds. XXI. A New Alkylation of Pyridazines with Nitromethane and Nitroethane
- Studies on the Heterocyclic Compounds. XX. The Reaction of 4-Cyano-3,6-dichloropyridazine with Amines
- Studies on the Heterocyclic Compounds. XIX. A Novel Ring Isomerization of 3-Ylideneaminoimidazo [4,5-c] pyridazines
- 複素環化合物の研究(第18報)Imidazo[1,2-c]-およびPyrimido[1,2-c]pyrimidine誘導体の合成
- Studies on the Pyridazine Derivatives. XVII. Structural Studies on the Product of 3-Hydrazino-4-aminopyridazine with Formic Acid (A Novel Ring Isomerization)
- Studies on the Pyridazine Derivatives. XVI. Reaction of 3-Alkoxy-4-nitro-(and 4,6-dinitro) pyridazine 1-Oxides with Amines
- Studies on the Pyridazine Derivatives. XIV. Synthesis and Reaction of Pyrimido [4,5-c] pyridazines
- Studies on the Synthesis of Pyridazine Derivatives. XIII. Synthesis of Imidazo-[4,5-d]- and v-Triazolo[4,5-d]pyridazine Derivatives and Reaction of 4-Alkoxy-v-triazolo[4,5-d]pyridazines with Various Amines
- Studies on the Synthesis of Pyridazine Derivatives. XII. Synthesis of 4,5-Diaminopyridazine Derivatives
- Studies on the Synthesis of Pyridazine Derivatives. X. Reaction of 3,6-Dimethoxy-4-nitropyridazine 1-Oxide with Alkyl Halides
- Studies on the Synthesis of Pyridazine Derivatives. IX. Synthesis of 10H-Pyridazino (3,2-b) quinazolin-10-one and Its Derivatives. (3)
- Pyridazine誘導体の合成研究(第8報) : Alkoxypyridazine N-Oxide類のエーテル交換反応について
- 3,6-Dimethoxy-4-nitropyridazine 1-Oxideとハロゲン化アルキルとの反応
- Pyridazine誘導体の合成研究(第7報) : 3,6-Dialkoxypyridazine 1-Oxide類とハロゲン化アルキルおよびハロゲン化アシルとの反応 その2
- Pyridazine誘導体の合成研究(第6報) : 3,6-Dialkoxypyridazine 1-Oxide類とハロゲン化アルキルおよびハロゲン化アシルとの反応 その1
- Pyridazine誘導体の合成研究(第5報) : 10H-Pyridazino[3,2-b]quinazolin-10-oneおよびその誘導体の合成 その2
- Studies on the Synthesis of Pyridazine Derivatives. XI. Reaction of 3,6-Dialkoxypyridazine 1-Oxide with Alkylhalides, Haloketones and Haloacid Esters, and Decomposition of Reaction Products
- 安定イオウイリドの研究(第9報)Dimethylsulfonium AcetylcarbamoylmethylideとIsoquinoline 2-Oxideとの反応
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- 安定イオウイリドの研究(第6報)Dimethylsulfonium AcetylmethoxycarbonylmethylideおよびDimethylsulfonium DiacetylmethylideとIsoquinoline 2-Oxideとの反応
- 安定イオウイリドの研究(第1報)Dimethyloxo-およびDimethylsulfonium BenzoylmethylideとAromatic Amine N-Oxide類との反応