Pyridazine誘導体の合成研究(第5報) : 10H-Pyridazino[3,2-b]quinazolin-10-oneおよびその誘導体の合成 その2
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概要
- 論文の詳細を見る
The structure of 4-oxo-3,4-dihydro-2-quinazolinepropionitrile (I), which had been presumed from its infrared and ultraviolet spectra, ^<1)> was established by the following sequence of reactions. Hydrolysis of I afforded 4-oxo-3,4-dihydroquinazoline-2-propionic acid (II), which was found to be identical with the substance obtained by palladium-carbon reduction of 4-oxo-3,4-dihydro-2-quinazolinacrylic acid (VII) prepared from 2-methyl-4(3H)-quinazolinone (V). This fact proves that I is 4-oxo-3,4-dihydro-2-quinazolinepropionitrile. Attempts to obtain II directly by the reaction of anthranilic acid and 3-cyanopro-pionamide failed to materialize and the product was found to be 2,2'-ethylenedi-4(3H)-quinazolinone.
- 公益社団法人日本薬学会の論文
- 1966-01-25
著者
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梁井 光二
Faculty Of Pharmaceutical Sciences Nagasaki University
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梁井 光二
長崎大学薬学部
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木下 敏夫
長崎大学薬学部
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中島 成子
長崎大学薬学部
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梁井 光二
Faculty of Pharmaceutical Sciences, Nagasaki University
関連論文
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- Studies on the Synthesis of Pyridazine Derivatives. IX. Synthesis of 10H-Pyridazino (3,2-b) quinazolin-10-one and Its Derivatives. (3)
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