水酸化鉄の解膠に関する研究(第4報)L-アラニンの解膠作用

概要

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Preparation of ferric hydroxide sol by using L-alanine was investigated in order to find a condition for obtaining a concentrated and stabilized sol in the near neutral pH range for manufacture of an iron-containing medicine. Ferric hydroxide was peptized by addition of its precipitate into L-alanine solution containing hydrochloric acid and boiling for 8 hr. The degree of peptization was evaluated by the concentration of ferric hydroxide in the sol thus formed. The concentration was determined by chelatomery after dissolving the colloidal particles into ferric ions. Although no peptization took place in the concentration range of 0.001-0.1 N of L-alanine, addition of a small amount of hydrochloric acid to it induced peptization. The degree of peptization depends on the concentration of L-alanine and hydrochloric acid. It was found that the prefered pH was 4-6 for the molar ratio between the precipitate and L-alanine of 0.1-0.2. Thus, the effect of L-alanine to peptize ferric hydroxide was recognized in the near neutral pH range. The mechanism of peptization was discussed from these results.
公益社団法人日本薬学会の論文
1978-10-25