ゼラチン, コンドロイチン硫酸混合膜の物理化学的研究(第3報)電解質透過性およびそのpH変化

概要

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The mixed membranes were prepared from gelatin and chondroitinsulfate (chs), whose fractions (X_<chs>) were 0.0,0.108,0.226,and 0.317. They were cross-linked by formaldehyde. The permeability of electrolytes (KCI and CaCl_2) through the membranes and their pH dependence were investigated in order to elucidate the effects of X_<chs> and the formation of complex between gelatin and chs on the permeability. The permeability (P^*) of KCl and CaCl_2 decreased with the content of the membrane constituent (W_M). The effect of X_<chs> on P^* depended on the kind of electrolytes ; permeability of KCl decreasded with increasing , X_<chs> but that of CaCl_2 was independent of it. In a strongly acidic region, effect of the concentration of hydrogen ion on P^* (KCl as solute) varied with the fraction of chs (X_<chs>) ; permeability through the membranes with X_<chs>=0.0 and 0.108 increased as pH of the bulk solution departed from the isoionic point of gelatin (pH 4.9), but that through the membrane of X_<chs>=0.226 decreased apparently at pH 2.2. For these systems, the relations between W_M and pH, and between P^* and W_M were investigated at various pH. From these results, it was found that the formation of the insoluble complex repressed the swelling of the membrane and decreased P^*.
公益社団法人日本薬学会の論文
1975-06-25