セファロチンナトリウム注射液の分解に伴う疼痛について

概要

論文の詳細を見る
By allowing the sodium cephalothin (CET) injection to stand, it decomposed to be colored and declined to be acidic. The effect of the injection, kept under different storage conditions, on the experimental animals was discussed. The pain to mice was examined by writhing response, by the intraperitoneal administration of the CET injections stored at constant 4°and 37°temperatures. A more remarkable writhing response was observed with the injection stored at 37°than that at 4°. The major degradation products of the injection were identified as acetic acid, deacetylcephalothin, and deacetoxycephalothin by various chromatographic and GC-MS techniques. The higher the storage temperature is, the larger the amount of degradation product is. Rate of decomposition of CET injection stored at 37°for 24 hr was about 30%, calculated from the amount of acetic acid produced. Neutralization of the CET injection stored at 37°for 24 hr with sodium hydroxide solution decreased the pain in mice. Consequently, it is assumed that induced pain is mainly attributed to acetic acid produced by degradation.
公益社団法人日本薬学会の論文
1980-11-25