Acridine Derivatives.III. : Preparation and Antitumor Activity of the Novel Acridinyl-Substituted Uracils
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概要
- 論文の詳細を見る
In an investigation of a new class of deoxyribonucleic acid (DNA)-intercalating antitumor agents, novel acridinyl-substituted uracils have been synthesized and evaluated for activity against L1210 leukemia in vivo, and against bacteria and fungus. These compounds were prepared by the novel enamine reaction between 9-chloroacridines and 6-aminouracils. The positional effects of substituents on the acridine ring showed that compounds bearing electron-withdrawing groups at the 3- or 6-position of the acridine ring were the most active.
- 公益社団法人日本薬学会の論文
- 1989-03-25
著者
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木邑 道夫
京都大学医学部附属病院
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木邑 道夫
Department Of Pharmacy Kyoto University Hospital
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加藤 旭
Niigata College of Pharmacy
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木邑 道夫
Niigata College of Pharmacy
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岡林 一蔵
Niigata College of Pharmacy
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