Studies on Novel Type Benzazocine. Syntheses and Pharmacological Properties of Novel Benzazocines

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概要

• 論文の詳細を見る

• The cyclization of 1-(substituted-allyl)-1,2,5,6-tetrahydro-2-benzylpyridines with Lewis acid was found to give novel benzomorphans consisted of a new four-ring system. The synthesized compounds have been found to possess a potent analgesic activity with low toxicity in mice in general, and some of them are several times as potent as pentazocine. The relationships between the analgesic activity and the molecular conformation of these compounds were also suggested in this paper.

• 公益社団法人日本薬学会の論文
• 1975-12-25

著者

• 木邑 道夫

  Department Of Pharmacy Kyoto University Hospital

• 木邑 道夫

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 山本 久夫

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 中島 毅

  Institute for Biological Science, Sumitomo Chemical Co., Ltd.

• 熱海 駿雄

  Institute for Biological Science, Sumitomo Chemical Co., Ltd.

• 古閑 良彦

  Institute for Biological Science, Sumitomo Chemical Co., Ltd.

• 山本 久夫

  Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 古閑 良彦

  Institute For Biological Science Sumitomo Chemical Co. Ltd.

• 中島 毅

  Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.

• 熱海 駿雄

  Institute For Biological Science Sumitomo Chemical Co. Ltd.

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