Benzodiazepines. X. Oxidation of Tetrahydro-1,4-benzo-diazepine Derivatives
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概要
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By ultraviolet (UV) irradiation in dimethyl sulfoxide (DMSO) or acetone tetrahydro-1,4-benzodiazepines of type 1 and 6-chloro-1-cyclopropylmethyl-4-phenyl-1,2,3,4-tetrahydroquinazolin-2-one (3) were oxidized to the corresponding dihydro compounds (2 and 4). 7-Chloro-1-methyl-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (1b) was prepared from 4-acetyl-7-chloro-1-methyl-2,3,4,5-tetrahydro-5-phenyl-1H-1,4-benzodiazepine (5) by oxidation with potassium permanganate followed by acid hydrolysis. Oxidation of other types of 4-acylbenzodiazepine derivatives was also examined.
- 公益社団法人日本薬学会の論文
- 1975-09-25
著者
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森 和夫
Pharmaceuticals Division Sumitomo Chemical Company Ltd.
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稲葉 茂穂
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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山本 久夫
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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石墨 紀久夫
Pharmaceuticals Division, Sumitomo Chemical Company, Ltd.
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山本 久夫
Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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稲葉 茂穂
Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.
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稲葉 茂穂
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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石墨 紀久夫
Sumitomo Pharmaceuticals Research Center
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