Benzodiazepines. XI. Further Examination of the Chromic Acid Oxidation of 2-Aminomethylindoles to 2,3-Dihydro-2H-1,4-benzodiazepin-2-ones
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概要
- 論文の詳細を見る
In the chromic acid oxidation of 2-aminomethyl-5-chloro-1-methyl-3-phenylindole (1) to 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (2), 1 reacts rapidly with chromic acid to form an oxidation intermediate A, which on acetylation with acetic anhydride gives 2-acetamido-2'-benzoyl-4'-chloro-N-methylacetanilide (3). The rate for formation of 2 from A has been determined by following the change of the quantities of 2 and 3 obtained by periodical sampling followed by quenching with acetic anhydride. The rate is first order with respect to the concentration of A.
- 公益社団法人日本薬学会の論文
- 1975-10-25
著者
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森 和夫
Pharmaceuticals Division Sumitomo Chemical Company Ltd.
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稲葉 茂穂
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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山本 久夫
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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石墨 紀久夫
Pharmaceuticals Division, Sumitomo Chemical Company, Ltd.
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山本 久夫
Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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稲葉 茂穂
Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.
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稲葉 茂穂
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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石墨 紀久夫
Sumitomo Pharmaceuticals Research Center
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