Benzodiazepines. IX. Oxidation of N-Phthalimidoacetylindoles

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概要

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• Chromic acid oxidation of N-phthalimidoacetylindoles (4) caused cleavage of the indole 2,3-double bond affording the expected 2'-benzoyl-2-phthalimidoacetanilides (5). Ozonolysis, on the other hand, resulted in the formation and isolation of the stable crystalline ozonides (6). Ozonides (6) as well as 5 were shown to be converted into benzodiazepin-2-one (7) by treatment with hydrazine hydrate.

• 公益社団法人日本薬学会の論文
• 1973-05-25

著者

• 森 和夫

  Pharmaceuticals Division Sumitomo Chemical Company Ltd.

• 山本 久夫

  Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.

• 石墨 紀久夫

  Pharmaceuticals Division, Sumitomo Chemical Company, Ltd.

• 稲葉 茂穗

  Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.

• 山本 久夫

  Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 稲葉 茂穂

  Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.

• 稲葉 茂穂

  Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 石墨 紀久夫

  Sumitomo Pharmaceuticals Research Center

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