^<13>C Nuclear Magnetic Resonance Studies of Antiinflammatory 2 (1H)-Quinazolinones

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概要

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• The ^<13>C NMR spectra of twelve 1-cyclopropylmethyl-4-phenyl-2 (1H)-quinazolinones including a potent anti-inflammatory agent SL-573 were investigated, and the all carbon resonances were assigned mainly by the off-resonance technique, substituent effects on the 4-phenyl groups and ^<13>C -^<19>F couplings. It is noteworthy that the good correlations were found between Hammett parameters δ_p and the ^<13>C chemical shifts of the para-substituted quinazolinone (1 and 7-12)-frame carbons in spite in spite of the large dihedral angles between the quinazolinone and phenyl ring planes (42.8°for SL-573).

• 公益社団法人日本薬学会の論文
• 1977-11-25

著者

• 木邑 道夫

  Department Of Pharmacy Kyoto University Hospital

• 正井 成一

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 木邑 道夫

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 山本 道博

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 広橋 敏之

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 山本 久夫

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 山本 久夫

  Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 山本 道博

  Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.

• 広橋 敏之

  Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.,

• 広橋 敏之

  Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.

• 山本 道博

  Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 正井 成一

  Institute For Biological Science Sumitomo Chemical Co. Ltd.

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