Synthetic Studies on Psychotropic Agents. I. A New Synthesis of 2'-Amino-4'-fluorobutyrophenone Derivatives using a Serective ortho-Amination of 2', 4'-Difluorobutyrophenone Derivatives
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概要
- 論文の詳細を見る
A new synthesis of 2'-amino-4'-fluoro-4-[4-hydroxy-4-(α, α, α-trifluoro-m-tolyl) piperidino] butyrophenone using a selective ortho-amination as a key step was described. The solvents and temperature effects on the selectivity for this ortho-amination of 2', 4'-difluoro-4-[4-hydroxy-4-(α, α, α-trifluoro-m-tolyl) piperidino] butyrophenone were investigated.
- 社団法人日本薬学会の論文
- 1978-08-25
著者
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山本 久夫
Research and Development Laboratories, Sapporo Breweries Ltd.,
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小野 圭一
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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勝部 純基
Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd., Institute for Biological
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笹島 紀久雄
Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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山本 久夫
Research And Development Laboratories Sapporo Breweries Ltd.
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山本 久夫
Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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勝部 純基
Pharmaceuticals Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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勝部 純基
Pharmaceuticals Research Laboratory Takarazuka Research Center Sumitomo Chemical Co. Ltd.
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笹島 紀久雄
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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