Studies on an Antitumor Polysaccharide RBS Derived from Rice Bran. II. : Preparation and General Properties of RON, an Active Fraction of RBS

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An antitumor polysaccharide RON was obtained by fractionating RBS (a saccharide derived from rice bran) as the non-adsorbed fraction on diethylaminoethyl-Sepharose CL-6B. RON is a dextran-like α-glucan composed mainly of α-1,6-glucosidic linkages with a small amount of C-3 branches. Methylation analysis showed that the molar ratio of non reducing terminal : 1,6-linkage : 1,3,6-linkage was 1 : 25 : 1.2. Its molecular weight is over 1000 kilodaltons (kDa), the specific rotation is [α]^<20>_D +205°, it contains almost no protein and no starch, and it contains a small amount of inorganic substances.RON has potent antitumor activities against syngeneic tumors, Meth-A fibrosacoma and Lewis lung carcinoma not only by intraperitoneal administration but also by oral administration, having optimum doses around 30 mg/kg. It is rare that an α-glucan such as RON has potent antitumor activities. Therefore, RON could be an interesting material to elucidate the relationship between the structure and antitumor activities of polysaccharides.
社団法人日本薬学会の論文
1988-09-25