Benzodiazepines. IV. A New Synthesis of 1-Diethylaminoethyl-substituted 1,4-Benzodiazepin-2-ones
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概要
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A new synthesis of 1-(2-diethylaminoethyl)-substituted 1,4-benzodiazepin-2-ones by ring enlargement of the corresponding 2-aminomethylindole derivatives is reported. A number of related compounds leading to these compounds were synthesized. Attempted chlorination of 5-chloro-1-(2-diethylaminoethyl)-3-(o-fluorophenyl) indole-2-carboxylic acid (VI) with thionyl chloride yielded 8-chloro-3,4-dihydro-2-ethyl-10-(o-fluorophenyl)-pyrazino [1,2-a] indol-1 (2H)-one (VII). Chlorination of 5-chloro-3-phenylindole-2-carboxylic acid derivative (VIII) with thionyl chloride gave two products, the expected acid chloride (XVI) and the dimer (XVII).
- 公益社団法人日本薬学会の論文
- 1971-02-25
著者
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稲葉 茂穂
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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山本 久夫
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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石墨 紀久夫
Pharmaceuticals Division, Sumitomo Chemical Company, Ltd.
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山本 久夫
Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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稲葉 茂穂
Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.
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稲葉 茂穂
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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石墨 紀久夫
Sumitomo Pharmaceuticals Research Center
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