Benzodiazepines. V. A Novel Synthesis of a 7-Nitro-1,4-benzodiazepine Derivative

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概要

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• The synthesis of 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (XVII) is described. 5-Nitro-3-phenylindole-2-carboxylic acid (X) was prepared by several methods and one of the most convenient methods was the treatment of p-nitrophenylhydrazine (VIII) with azlactone (V). A by-product isolated from the synthesis of XVII was shown to be 2-(2-benzoyl-4-nitroanilino)-N-methylacetamide (XVIII) by a comparison with an authentic sample prepared by independent synthesis.

• 公益社団法人日本薬学会の論文
• 1971-04-25

著者

• 森 和夫

  Pharmaceuticals Division Sumitomo Chemical Company Ltd.

• 稲葉 茂穂

  Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.

• 山本 久夫

  Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.

• 石墨 紀久夫

  Pharmaceuticals Division, Sumitomo Chemical Company, Ltd.

• 山本 久夫

  Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 稲葉 茂穂

  Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.

• 稲葉 茂穂

  Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 石墨 紀久夫

  Sumitomo Pharmaceuticals Research Center

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