Benzodiazepine. XIII. Syntheses of 1,4-Benzodiazepine Derivatives
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概要
- 論文の詳細を見る
Oxidation of 3-methyl-or benzyl-substituted or unsubstituted 2-aminomethylindole was described. 1,4-Benzodiazepin-2-one derivatives (VIIa-c) were synthesized by oxidative ring enlargement of corresponding 2-aminomethylindole derivatives (VIa-c). Also, oxidation of VIa and VIc with O_3 gave 1,4-benzodiazepin-2,5-dione derivatives VIIIa and VIIIc, respectively, oxidation of VIa with CrO_3 gave isatin derivative IX and oxidation of VIc with H_2O_2 afforded 2-oxindole derivative X as unexpected product.
- 公益社団法人日本薬学会の論文
- 1976-05-25
著者
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赤津 光洋
Pharmaceuticals Divisiou Sumitomo Chemical Co. Ltd.
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稲葉 茂穂
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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廣橋 敏之
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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山本 久夫
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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山本 久夫
Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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稲葉 茂穂
Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.
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稲葉 茂穂
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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廣橋 敏之
Pharmaceuticals Divisiou Sumitomo Chemical Co. Ltd.
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