Benzodiazepines. VII. Pyrazino [1,2-α] indole-1 (2H)-ones and Their Conversion to 2,3-Dihydro-1H-1,4-benzodiazepines
スポンサーリンク
概要
- 論文の詳細を見る
A new synthetic route for the preparation of 2,3-dihydro-1H-1,4-benzodiazepines (6) is described. It consists of performing successively N-cyanomethylation of ethyl indole-2-carboxylates (1), reduction of cyano group, oxidation of 1-aminoethylindole derivatives (3 or 4) and finally hydrolysis of 2,3-piperazinediones (5). In an alternative synthesis of the key intermediate 4a, intramolecular alkylation of N-(2-chloroethyl) indole-2-carboxamide (11) gave a mixture of 4a and 2-oxazolinylindole (12).
- 公益社団法人日本薬学会の論文
- 1972-08-25
著者
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稲葉 茂穂
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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山本 久夫
Pharmaceuticals Divisiou, Sumitomo Chemical Co., Ltd.
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岡本 忠士
Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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石墨 紀久夫
Pharmaceuticals Division, Sumitomo Chemical Company, Ltd.
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山本 久夫
Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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稲葉 茂穂
Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.
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稲葉 茂穂
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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石墨 紀久夫
Sumitomo Pharmaceuticals Research Center
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