Studies on the Syntheses of Azabicyclo [3,3,1] non-6-enes by the Novel Cyclization Reaction of Tetrahydropyridines with Lewis Acid

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概要

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• Previously the authors have reported that the cyclization reaction of 1-(substitutedallyl)-2-benzyl-3,4-dimethyl-1,2,5,6-tetrahydro-pyridines with Lewis acid gives the novel type benzazocines which have potent analgesic activity. By examining in more details the novel cyclization reaction, it was found that this reaction was one of the available methods for the synthesis of varous 1-azabicyclo [3,3,1] non-6-enes. Some of them had analgesic activity in acetic acid Writhing test. Moreover, catalytic hydrogenation of the 1-azabicyclo [3,3,1] non-6-enes afforded the corresponding 1-azabicyclo [3,3,1] nonanes which are useful as agricultural chemicals and as additives or additive precursors for hydrocarbon compositions ranging from gasoline fractions through middle distillate fuels and lubricating oils.

• 公益社団法人日本薬学会の論文
• 1976-03-25

著者

• 木邑 道夫

  Department Of Pharmacy Kyoto University Hospital

• 木邑 道夫

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 山本 久夫

  Institute for Biological Science, Sumitomo Chemical Co. Ltd.

• 中島 毅

  Institute for Biological Science, Sumitomo Chemical Co., Ltd.

• 稲葉 茂穂

  Institute for Biological Science, Sumitomo Chemical Co., Ltd.

• 山本 久夫

  Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 稲葉 茂穂

  Research and Development Center, Pharmaceuticals Division Sumitomo Chemical Co., Ltd.

• 稲葉 茂穂

  Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.

• 中島 毅

  Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.

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