麻痺性貝毒成分の化学的還元的変換二枚貝における麻痺性貝毒成分の相互変換に関連して

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Gonyautoxin-1,4 (GTX_<1-4>), -2,3 (GTX_<2-3>) and saxitoxin (STX) group (neoSTX, STX) were isolated from the toxic plankton Protogonyaulax tamarensis in Funka Bay, Hokkaido. Some chemical properties of the toxins were attempted to be examined. The cells of P. tamarensis cultured in BSW-4 medium were extracted with acidic ethanol. The extract was applied successively to three types of column chromatography on Bio-Gel P-2,Amberlite CG-50 and Bio-Rex 70. The toxins obtained were finally purified by cellulose acetate membrane electrophoresis. GTX_<1-4>, GTX_<2-3> and STX group thus obtained were treated, respectively, by two methods as described below. One was treatment by heating at 60℃ for 1 h with Raney nickel, and the other was treatment by heating at 90℃ for 20 min with hydroiodic acid and red phosphorus. The composition of reaction products obtained was examined by fluorodensitometry. The results were as follows. By the treatment with Raney nickel, GTX_<1-4> was partially reduced to GTX_<2-3>. Namely, GTX_<1-4> (GTX_1 : 93%, GTX_4 : 7%) was treated with Raney nickel, to give a mixture of GTX_1 (62%), GTX_4 (11%), GTX_2 (18%) and GTX_3 (9%). However, GTX_<2-3> were not reduced to other PSP components, and there was not a remarkable change in the composition of STX group. By the treatment with hydroiodic acid and red phosphorus, GTX_<1-4>, GTX_<2-3> and STX groups were converted to the components whose electrophoretic behaviors differed from PSP standards (GTX_<1-4>, neoSTX, STX) used at this time.
公益社団法人日本薬学会の論文
1986-06-30

麻痺性貝毒成分の化学的還元的変換二枚貝における麻痺性貝毒成分の相互変換に関連して

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麻痺性貝毒成分の化学的還元的変換 二枚貝における麻痺性貝毒成分の相互変換に関連して

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麻痺性貝毒成分の化学的還元的変換二枚貝における麻痺性貝毒成分の相互変換に関連して