アメマス肝ホモジネ-トによる塩化ニトロビフェニルエ-テル(CNBE)類および誘導体の変異原物質への転換〔英文〕

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The ability of white-spotted char liver homogenate to convert chlorinated nitrobiphenyl ethers and their nitroso and amino derivatives to mutagens was investigated by using Salmonella/microsome test. p-Nitrobiphenyl ether (p-NO2), 3-chlor p-nitrobiphenyl ether (3-CNO2), 4-chloro p-nitrobiphenyl ether (4-CNO2) and all the nitroso derivatives used induced mutations in Salmonella typhimurium without liver homogenate. Mutagenicities of these compounds were closely related to the bacterial reduction process. While all the amino derivatives used showed no mutagenic activity without liver homogenate. With liver homogenate, the mutagenic activities of p-NO2, 3-CNO2and 4-CNO2 slightly increased while those of the nitroso derivatives greatly increased, and paminobiphenyl ether and 4-chloro p-aminobiphenyl ether among the amino derivatives showed the mutagenic activities. The results obtained reflected that white-spotted char liver homogenate had the ability to convert these compounds to mutagens. The mutagenic activity of these compounds was affected by not only the number of chlorine but also by its position on phenoxy group in the molecules.
日本水産學會の論文