Kelthaneの生体内運命に関する研究(第1報)^3H-Kelthaneのマウスにおける生体内分布と排泄

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Distribution and excretion of ^3H-1,1-bis (4-chlorophenyl) 2,2,2-trichloroethanol (^3H-kelthane) after oral dosaze were studied in mice. In the distribution study of ^3H-kelthane, its radioactivity was detected in various tissues, indicating extensive uptake of this compound. The radioactivity distributed in each organ in mice reached a maximum after 24-48 hr and rapidly decreased thereafter with the exception of body fat. In particular, high level of radioactivity and its prolonged retention were observed in the body fat in mice. Approximately 60 % of the administered radioactivity was excreted in the urine (20 %) and feces (40 %) of mice within 96 hr, implying that fecal excretion is the major elimination route in the oral administration of kelthane.
公益社団法人日本薬学会の論文
1980-08-31