Formic Acid Reduction. XIII. Formate Reaction of the Compounds possessing the Carbon Bound to Both Oxygen and Nitrogen
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概要
- 論文の詳細を見る
There has been introduced a new type of formic acid reduction of the compounds in which both amine nitrogen and ether oxygen are bound to the same carbon. With series of N-(α-butoxybenzyl) dialkylamines, N-(butoxymethyl) dialkylamines and 3-methyloxazolidines, the reaction was normally carried out on heating with distillable formate, TMAF given by 5HCO_2H・2N (CH_3)_3,to give tertiary amines, resulting in reductive fission at the carbon-oxygen bond. Mode of the reduction was clarified by the technique of using deuterated formic acids, in which formyl hydrogen of formic acid is transferred to the carbon of the carbon-oxygen bond. On the basis of this result a possible mechanism is described.
- 社団法人日本薬学会の論文
- 1972-10-25
著者
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伊藤 敬一
Hokkaido College Of Pharmacy
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関屋 実
Shizuoka College of Pharmacy
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伊藤 敬一
Shizuoka College of Pharmacy
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大庭 均
Shizuoka College of Pharmacy
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Ito Keiichi
Hokkaido College Of Pharmacy
関連論文
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- Thermal Rearrangements of Allyl 2,2-Dichloro-, 1,2-Dichloro- and 1,2,2-Trichloro-substituted Vinyl Sulfides
- Novel Rearrangements of α-N-Alkylamido-substituted Sulfides and Sulfones
- Syntheses and Reactions of Phenylthio-and Propylthioacetylenic Compounds
- Enantioface-Differentiating Epoxidation of Alkylidenemalononitriles with Molecular Oxygen, catalyzed by Chiral Tertiary Amines
- Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
- A New Insertion Reaction of Diazoalkanes with Dialkylaminomethyl Esters of Dialkyldithiocarbamic Acid and of Ethylxanthic Acid
- Chlorinolyses of Alkyl (or Aryl) Phthalimidomethyl Sulfoxides with Sulfuryl Chloride, Chlorine and Thionyl Chloride
- Nucleophilic Substitution of Alkyl (or Aryl) Imidomethyl Sulfones. A New Convenient Synthesis of Alkane (or Arene) sulfinates
- Decarboxylation Reaction. VIII. Reaction of Electron-deficient Carbon-Carbon Double Bonds with Trichloroacetic Acid. A Unique 1,1-Dichlorocyclopropane Formation through β-Trichloromethylation
- Formic Acid Reduction. XXVI. α, β-Reduction of Conjugated Nitriles with Formic Acid
- Decarboxylation Reactions. V. Reaction of N-Benzylideneanilines with Propiolic Acid
- Formic Acid Reduction. XXIV. Path of the Reductive Fission of the Centered β-Carbon Bond of Alkylidenebisketones
- Formic Acid Reduction. XXIII. Kinetic Studies on the Formic Acid Reduction of Carbon-Carbon Double Bond Adjacent to Carbonyl
- Formic Acid Reduction. XXII. Reaction of α, N-Diphenylnitrone with Formic Acid
- Formic Acid Reduction. XXI. Reductive Cleavage Reaction of p-Dimethylamino-substituted Triphenylmethanes induced by Formate
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- Formic Acid Reduction. XIX. Formic Acid Reduction of 4-Dialkylaminosubstituted Nitro-, Nitroso-, Azoxy-and Azobenzenes
- Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
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- Preparations of N-Alkylthiomethyl and N-Amidomethyl Derivatives of Amino Acids
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- Reductive Cleavage Reaction of N, N'-, N, O- and N, S-Linked Alkylidene Compounds by Sodium Borohydride
- On Behaviors of N-(Dialkylaminomethyl) imides and-amides toward Nucleophiles
- Reaction of N-(Dialkylaminomethyl) amides and N-(α-Dialkylaminobenzyl) amides with Sulfides and Cyanide
- Formic Acid Reduction. XV. Reaction of N-Methyl and N-Formyl Derivatives of p-Phenylenediamine with Formates. N-Methylation of Formanilides
- Formic Acid Reduction. XIII. Formate Reaction of the Compounds possessing the Carbon Bound to Both Oxygen and Nitrogen
- Catalytic Hydrogenation of Tetrahydro-4H-1,3-oxazin-4-ones and 4-Oxazolidinones
- Catalytic Hydrogenolyses of Benzylidene Compounds Bound to Two Oxygens, Two Nitrogens and Both Oxygen and Nitrogen
- バルビツール酸およびその誘導体のジアゾメタンによるメチル化
- Catalytic Hydrogenation of Hydroamide in the Presence of Ammonia and of Butylamine
- Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
- Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
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- Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
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- 1,3-Dipolar Cycloaddition Leading to N-Acylated Pyrrolidines and 2,5-Dihydropyrroles
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- Facile Syntheses of Xanthines from Uric Acids
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- Reaction of Amide Homologs. XXVI. On the Products obtained from the Reaction of N-Alkylphenylacetamides with Phosphoryl Chloride
- Facile Syntheses of Hypoxanthine and Adenine
- Azole Series. III. Reactions of 2-Acylamino-2-cyanoacetamides leading to 5-Aminooxazole-4-carboxamides and to Oxazolo [5,4-d] pyrimidines
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- Reaction of N, N-Dialkylaminomethyl Arenesulfonates with Diazoalkanes
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- Reaction of Amide Homologs. IX. Catalytic Hydrogenation of Azomethines in the Presence of Amide and its Mechanism.
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