Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
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概要
- 論文の詳細を見る
The formic acid reduction of 1,1'-benzylidenedipiperidine (1) was kinetically investigated by the carbon dioxide trapping method. Rate data gave the rate equation, v=k_<obs> [1] [HCOOH]. The initial mono- and diprotonation of 1 occur in equilibrium, and monoprotonated form is proposed to be an intermediate for the reduction to 1-benzylpiperidine. The isotope effect value (2.69) and the negative ρ substituent effect (similar to that of the formic acid reduction of N-benzylideneaniline) suggest that the reduction of 1 involves the same intermediate step of decarboxylation of the formic acid ester of the α-amino alcohol.
- 社団法人日本薬学会の論文
- 1980-10-25
著者
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関屋 実
School Of Pharmaceutical Sciences University Of Shizuoka
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鈴木 邦夫
School Of Pharmaceutical Sciences University Of Shizuoka
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鈴木 邦夫
Shizuoka College of Pharmacy
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関屋 実
Shizuoka College of Pharmacy
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府川 秀道
Shizuoka College of Pharmacy
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