Reactions of α-Alkyl- and α-Aryl-substituted N-Benzylideneamines with Trihaloacetylating Agents

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概要

• 論文の詳細を見る

• Reactions of imines with trichloroacetylating agents rely upon their structural differences. 3,3-Dichloro-2-azetidinone formation was effected by the reaction of α-arylsubstituted N-benzylideneamines similarly to that of N-benzylideneamines. The imines, of which imino carbons are bound to alkyls possessing at least one hydrogen at C_1 of the alkyls, however, reacted with trichloroacetic anhydride and trichloroacetyl chloride to give β-trichloroacetylated enamines. In the reaction with trifluoroacetic anhydride in place of trichloroacetic anhydride N-trifluoroacetylenamines were obtained instead, but the products easily undergo N→C migration on heating in xylene to give β-trifluoroacetylated enamines. Acid-catalyzed quinoline ring-closures of the β-trihaloacetylated enamines obtained above are also described.

• 公益社団法人日本薬学会の論文
• 1977-06-25

著者

• 関屋 実

  School Of Pharmaceutical Sciences University Of Shizuoka

• 関屋 実

  Shizuoka College of Pharmacy

• 森本 俊明

  Shizuoka College of Pharmacy

関連論文

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