Primary Aminomethylation at the α-Position of Carboxylic Acids and Esters. Trimethylsilyl Triflate-Catalyzed Reaction of Ketene Silyl Acetals with N, N-Bis (trimethylsilyl) methoxymethylamine
スポンサーリンク
概要
- 論文の詳細を見る
A new, general method for the synthesis of β-aminocarboxylic esters (9) and acids (10) was developed. The introduction of a primary aminomethyl unit at the α-position of carboxylic esters (2) and acids (3) was achieved in high yields by the silyl trifluoromethanesulfonate (6)-catalyzed reaction of ketene silyl acetals (4) and ketene bissilyl acetals (5) with N, N-bis (trimethylsilyl)-methoxymethylamine (1). A possible mechanism for the reaction is proposed.
- 社団法人日本薬学会の論文
- 1985-06-25
著者
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関屋 実
School Of Pharmaceutical Sciences University Of Shizuoka
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関屋 実
Shizuoka College of Pharmacy
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森本 俊明
Shizuoka College of Pharmacy
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岡野 幸次
Shizuoka College of Pharmacy
関連論文
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