Decarboxylation Reactions. IX. Reaction of Enamines with Trichloroacetic Anhydride
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概要
- 論文の詳細を見る
A reaction of β, β-dialkylenamines with trichloroacetic anhydride has been found to proceed with decarboxylation resulting in both β-trichloroacetylation and α-trichloromethylation. Mechanistically this reaction path involves an intermediate, β-trichloroacetylated iminium trichloroacetate, which suffers decarboxylation resulting in α-trichloromethylation. This course of the reaction was also stepwise processed by allowing to react with trichloroacetyl chloride, which was replaceable by p-nitrobenzoyl chloride, and succeedingly with trichloroacetate. The above reactions have provided a general method of synthesis of tertiary amines possessing both α-trichloromethyl and β-trichloroacetyl. Hydrolysis of these products is also described.
- 公益社団法人日本薬学会の論文
- 1978-05-25
著者
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関屋 実
School Of Pharmaceutical Sciences University Of Shizuoka
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関屋 実
Shizuoka College of Pharmacy
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森本 俊明
Shizuoka College of Pharmacy
関連論文
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