One Step Syntheses of Adenine, Xanthine and Guanine from Phenylazomalonic Acid Derivatives
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概要
- 論文の詳細を見る
Facile one step purine syntheses from phenylazomalonic acid derivatives are described. Adenine, xanthine and guanine were synthesized directly from phenylazomalononitrile, N-(2-cyano-2-phenylazoacetyl) urea and 2-cyano-2-phenylazoacetylguanidine, respectively, by catalytic hydrogenation in formamide in the presence of ammonia (in the latter two the presence of ammonia was not indispensable) in excellent or good yields. Course of the reaction was revealed to involve the initial pyrimidine ring-closure followed by the imidazole ring-closure.
- 社団法人日本薬学会の論文
- 1976-06-25
著者
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関屋 実
School Of Pharmaceutical Sciences University Of Shizuoka
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寺尾 良保
Shizuoka College of Pharmacy
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関屋 実
Shizuoka College of Pharmacy
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鈴木 次郎
Shizuoka College of Pharmacy
関連論文
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