Reaction of Amide Homologs. XIII. Catalytic Hydrogenolysis of N-Acylaminomethyl and N-Arylsulfonamidomethyl Compounds

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概要

• 論文の詳細を見る

• Hydrogenolysis of N-acylaminomethyl and additionally N-arylsulfonamidomethyl compounds attached to a variety of amines, not only under conditions with Raney nickel catalyst under high hydrogen pressure, but also, in some cases, under those with palladium-on-charcoal catalyst under ordinary hydrogen pressure, was investigated in a view of the factors affecting the rate. Solvent and variation in the structure were recognized to be major rate-determining factors. Comparison of the rates of a large number of the compounds indicates that the hydrogenolysis is more facilitated with increase of electron density at amine nitrogen and decrease of that at each acylamino and sulfonamido nitrogen. The reaction scope was established and the application in N-methylation of amine was generalized.

• 公益社団法人日本薬学会の論文
• 1966-09-25

著者

• 伊藤 敬一

  Hokkaido College Of Pharmacy

• 関屋 実

  Shizuoka College of Pharmacy

• 伊藤 敬一

  Shizuoka College of Pharmacy

関連論文

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• Thermal Rearrangements of Allyl 2,2-Dichloro-, 1,2-Dichloro- and 1,2,2-Trichloro-substituted Vinyl Sulfides
• Novel Rearrangements of α-N-Alkylamido-substituted Sulfides and Sulfones
• Syntheses and Reactions of Phenylthio-and Propylthioacetylenic Compounds
• Enantioface-Differentiating Epoxidation of Alkylidenemalononitriles with Molecular Oxygen, catalyzed by Chiral Tertiary Amines
• Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
• A New Insertion Reaction of Diazoalkanes with Dialkylaminomethyl Esters of Dialkyldithiocarbamic Acid and of Ethylxanthic Acid
• Chlorinolyses of Alkyl (or Aryl) Phthalimidomethyl Sulfoxides with Sulfuryl Chloride, Chlorine and Thionyl Chloride
• Nucleophilic Substitution of Alkyl (or Aryl) Imidomethyl Sulfones. A New Convenient Synthesis of Alkane (or Arene) sulfinates
• Decarboxylation Reaction. VIII. Reaction of Electron-deficient Carbon-Carbon Double Bonds with Trichloroacetic Acid. A Unique 1,1-Dichlorocyclopropane Formation through β-Trichloromethylation
• Formic Acid Reduction. XXVI. α, β-Reduction of Conjugated Nitriles with Formic Acid
• Decarboxylation Reactions. V. Reaction of N-Benzylideneanilines with Propiolic Acid
• Formic Acid Reduction. XXIV. Path of the Reductive Fission of the Centered β-Carbon Bond of Alkylidenebisketones
• Formic Acid Reduction. XXIII. Kinetic Studies on the Formic Acid Reduction of Carbon-Carbon Double Bond Adjacent to Carbonyl
• Formic Acid Reduction. XXII. Reaction of α, N-Diphenylnitrone with Formic Acid
• Formic Acid Reduction. XXI. Reductive Cleavage Reaction of p-Dimethylamino-substituted Triphenylmethanes induced by Formate
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• Catalytic Hydrogenolyses of Benzylidene Compounds Bound to Two Oxygens, Two Nitrogens and Both Oxygen and Nitrogen
• バルビツール酸およびその誘導体のジアゾメタンによるメチル化
• Catalytic Hydrogenation of Hydroamide in the Presence of Ammonia and of Butylamine
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• Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine
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• ギ酸による還元反応(第2報) : 含窒素芳香環化合物の還元
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