Reaction of Amide Homologs. XVIII. Catalytic Hydrogenation of N-Arylmethylene-1-acylamino-1-arylmethylamines and Hydroamides in the Presence of Formamide and Related Studies

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概要

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• Catalytic hydrogenations of both series of the compounds, N-arylmethylene-1-acylamino-1-arylmethylamines and hydroamides, over Raney nickel catalyst were examined under both conditions, in the presence of formamide and in the absence of it. While under the latter condition either of the hydrogenations proceeded to give secondary amine at least as one of the principal reduction products, under the former condition resulted in the predominant formation of N-formylated priomary amine. In correlation with the previously reported azomethine-formamide hydrogenation the reaction paths for the hydrogenations influenced by formamide were revealed to be of involving intermediates, azomethine, aldimine, and N-arylmethylene-1-formamido-1-arylmethylamine (in the case with hydroamides).

• 社団法人日本薬学会の論文
• 1967-06-25

著者

• 伊藤 敬一

  Hokkaido College Of Pharmacy

• 関屋 実

  Shizuoka College of Pharmacy

• 伊藤 敬一

  Shizuoka College of Pharmacy

• 鈴木 次郎

  Shizuoka College of Pharmacy

• 原 明

  Shizuoka College Of Pharmacy

• 田中 康三

  Shizuoka Colloge of Pharmacy

関連論文

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