Inhibition of Transglutaminase by Synthetic Tyrosine Melanin(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
Transglutaminases catalyze the cross-linking and amine incorporation of proteins, and are implicated in various biological phenomena. Previously, we found a high molecular mass transglutaminase-inhibitory substance produced by Streptomyces lavendulae Y-200 that appeared to be a melanin substance. Here, we report that synthetic tyrosine melanin inhibited various types of transglutaminases. Tyrosine melanin inhibited tissue-type transglutaminase in a competitive manner with a glutamine substrate, and also inhibited the cross-linking of casein catalyzed by a tissue-type transglutaminase. The melanized hemolymph of the silkworm and melanin solutions prepared from melanin precursors inhibited tissue-type transglutaminase. These results suggested that the melanin substances generally inhibit transglutaminases.
- 社団法人日本農芸化学会の論文
- 2002-06-23
著者
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NATSUKA Shunji
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology
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ICHIKAWA Akira
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology
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IKURA Koji
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology
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NAKAKITA Shin-ichi
Department of Chemistry, Graduate School of Science, Osaka University
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Ichikawa A
Department Of Applied Biology Kyoto Institute Of Technology
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Natsuka S
Department Of Chemistry Graduate School Of Science Osaka University
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Natsuka Shunji
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Ikura K
Kyoto Inst. Technol. Kyoto Jpn
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Ikura Koji
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Ikura Koji
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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OTOMO Chiemi
Department of Applied Biology, Kyoto Institute of Technology
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WAKAMATSU Kazumasa
School of Health Sciences, Fujita Health University
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ITO Shosuke
School of Health Sciences, Fujita Health University
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TAOGUCHI Shin-ichi
Department of Applied Biology, Kyoto Institute of Technology
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Wakamatsu Kazumasa
School Of Health Sciences Fujita Health University
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Ikura K
Department Of Applied Biology Kyoto Institute Of Technology
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Nakakita S
Department Of Chemistry Graduate School Of Science Osaka University
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Ito Shosuke
School Of Health Sciences Fujita Health University
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Otomo Chiemi
Department Of Applied Biology Kyoto Institute Of Technology
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Ichikawa Akira
Department Of Applied Biology Graduate School Of Science And Technology Kyoto Institute Of Technolog
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Nakakita Shin-ichi
Division Of Functional Glycomics Life Science Research Center Institute Of Research Promotion Kagawa
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Taoguchi Shin-ichi
Department Of Applied Biology Kyoto Institute Of Technology
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