11 酢酸メバロン酸経路と非酢酸メバロン酸経路間の物質のクロストークが植物の生長に及ぼす影響について

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Isoprenoids in higher plants are produced via two independent biosynthetic pathways : the mevalonate (MVA) pathway in the cytoplasm and the non-mevalonate 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway in plastids. Sterols and brassinosteroids are formed via MVA pathway, whereas phytol, carotenoids, abscisic acid, gibberellin intermediates and chlorophyll side chains are synthesized via MEP pathway. It has been previously suggested that common intermediate(s) such as isopentenyl diphosphate (IPP) via the two pathways can be exchanged between the cytoplasm and plastids. However, the issue of whether the exchanged products reflect efficient synthesis of functional isoprenoids remains unresolved. To examine whether mevalonic acid can flow into the MEP pathway, we fed exogenous mevalonic acid to the Arabidopsis albino mutant cla1-1,a null mutant of the first-step enzyme in the MEP pathway. This resulted in the partial recovery of chlorophyll accumulation and thylakoid membrane stacking in chloroplasts in the light, and the formation of prolamellar bodies and plastoglobuli in etioplasts in the dark. By contrast, exogenous lovastatin, an inhibitor of mevalonic acid biosynthesis, induced complete depigmentation and further inhibitions of chlorophyll fluorescence intensity and plastid development than those in cla1-1 plants in the light. Our observations suggested that mevalonic acid-derived products flow from the MVA pathway to the MEP pathway in limited amounts and contribute to the formation of functional plastidic isoprenoids, such as the chlorophylls and carotenoids required for plastid development. This crosstalk mechanism between two pathways may compensate limited growth when there is a deficiency in the MVA pathway or MEP pathway.
植物化学調節学会の論文
2002-10-31

11 酢酸メバロン酸経路と非酢酸メバロン酸経路間の物質のクロストークが植物の生長に及ぼす影響について

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