D-35 新規ブラシノステロイド生合成阻害剤の構造活性相関及び作用部位

概要

論文の詳細を見る
Some of cytochrome P450 (P450) inhibitors are triazole analogs. Because plant P450s are also affected by triazole analogs, we designed and synthesized triazole analogs as biosynthetic inhibitors of BRs (Brassinosteroids). Effect of chemicals synthesized in this study on BRs biosynthesis was examined using Arabidopsis seedling test and rice lamina inclination test. One of analogs, MA 91 showed inhibitory effect on Arabidopsis seedling at 1mM, which were recovered by BR treatmen. Study on structure-activity relationship of synthetic compounds indicated that biological activities of these compounds varied significantly according to the difference of functional group of benzene ring and a substituent at C2 where hydroxyl group attached. The data suggested that MA 91 should block' step(s) in the biosynthetic pathway of BRs. We named Ma 91 as Brz.
植物化学調節学会の論文
1998-10-01