44 シロイヌナズナの生長に及ぼすHMG-CoAレダクターゼ阻害剤の影響

概要

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3-hydroxy-3-methylglutaryl CoA reductase (HMGR) is a key enzyme in the mevalonate pathway. it is thought that HMGR regulates the biosynthesis of phytohormones and the farnesylation of some protein. It has been revealed that the inhibition of HMGR inhibits cell division by using tobacco BY-2 cells. When an inhibitor of HMGR is applied to whole plant, however, its effect has not been well understood. Here, we examined how the treatment of an inhibitor of HMGR, lovastatin, influences the growth of Arabidopsis thaliana plant. Seeds of Arabidopsis thaliana were cultured in MS liquid medium containing lovastatin 0 to lμM under the light or the dark. As a result, lovastatin inhibited elongation of roots and hypocotyls, enlargement of cotyledons, and the development of the inflorescence under the light, and also inhibited elongation of roots and hypocotyls under the dark. These results indicate that lovastatin inhibits not only cell division but also cell elongation. A treatment of geranyl pyrophosphate, gibberellin or brassinolide recovered the elongation of hypocotyls under the light but not under the dark. Therefore, there may be different mechanisms to elongate cells between under the light and the dark.
植物化学調節学会の論文
2001-10-09