1 緑茶カテキンがヒト口腔扁平上皮癌細胞株の増殖とテロメラーゼ活性に及ぼす影響(第474回大阪歯科学会例会)

概要

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We investigated the effect of green tea on cellular proliferation and telomerase activity in the human oral squamous cell carcinoma cell lines HSC-4 (well differentiated) and HSC-3 (poorly differentiated). HSC-4 and HSC-3 cells were incubated following treatment with or without (-)-epigallocatechin-3-gallate (EGCG), and with or without (-)-epicatechin (EC), at various concentrations. Although EC did not significantly inhibit cellular proliferation in either cell line, EGCG inhibited it in a dose and time dependent manner. Although the telomerase activity of HSC-3 cells was not inhibited, that of HSC-4 was inhibited in a dose and time dependent manner. When HSC-4 cells were treated with EC in the presence of EGCG, there was a synergism in the inhibition of cellular proliferation, telomerase activity and the expressions of hTERT and MMP-9 mRNA. These results indicated that antitumor effects of green tea are closely related to telomerase activity in well differentiated oral squamous cell carcinoma.
大阪歯科学会の論文
2000-12-25