2 ヒト口腔前癌病変と扁平上皮癌およびマウス各種臓器におけるelk-1遺伝子の発現について(第470回大阪歯科学会例会)

概要

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The elk-1 oncogene is a member of the est family and regulates gene expression in a variety of biological processes.We used molecular biological techniques to investigate the expression pattern of the elk-1 gene in mice and in human oral precancerous lesions and squamous cell carcinomas.elk-1 mRNA was moderately expressed in erythroplakia and leukoplakia, weakly expressed in normal gingiva, and strongly expressed in squamous cell carcinomas.Furthermore, elk-1 mRNA was detected in mice From 8 to 12 days of gestation.It was weak in the ovaries, and was not detected in the intestine, stomach, uterus, kidney, spleen, liver or testes.These results suggest that elk-1 may play an important role in the development of oral precancerous lesions and squamous cell carcinomas.
大阪歯科学会の論文
2000-03-25