1 4-nitroquinoline 1-oxide誘発ラット舌癌発生過程における細胞動態とP型カドヘリンとの関連 (第477回大阪歯科学会例会)

概要

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We did immunohistochemical examinations of the cell growth factor BrdU, cyclin D1 and the cell adhesion molecular P-cadherin (P-CD) during carcinogenesis in the tongue. In normal cells and those with hyperkeratoosis, BrdU and cyclin D1 localized only in the nuclei of basal cells, and P-CD was expressed only in the basal cell membrane. In dysplasia, BrdU was expressed in the basal cells, and cyclin D1 extended to a wide area, including the basal cell layer and spinous cell layer. P-CD was expressed from the basal cells to the spinous cell membrane. In carcinomas, BrdU and cyclin D1 immunoreactive cells were localized in the peripheral layer of the tumor nests. P-CD was expressed in cancer cells except in the tumor nests. The expression of cell growth factor and P-CD corresponded to the development of carcinogenesis.
大阪歯科学会の論文
2001-06-25