2 顎関節滑液コンドロイチン硫酸由来不飽和二糖の微量定量とその臨床的意義 (第453回大阪歯科学会例会)

概要

論文の詳細を見る
We collected synovial fluid from temporomandibular joints with internal derangement and pain. Glycosaminoglycans were liberated by digestion with pronase E, and precipitated with 5% cetylpyridinium chloride and 95% ethanol. Unsaturated disaccharide isomers of chondroitin sulfate, obtained following chondroitinase ACII digestion, were analyzed by high-performance liquid chromatography. We found ΔDi-0 S and ΔDi-6 S in the chondroitin sulfate of the fluid from most of the diseased joints. There were significant differences in the amount of ΔDi-0 S (p<0.01) and ΔDDi-6 S (p<0.05) in the synovial fluid of the diseased and healthy joints. These results suggest that chondroitin sulfate in the synovial fluid provides a useful indicator of the degree of temporomandibular joint disease.
大阪歯科学会の論文
1997-06-25