12 4-nitroquinoline 1-oxide誘発ラット舌癌発生過程におけるp21^<WAF1/Cip1>の発現(第511回大阪歯科学会例会)

概要

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We investigated immunohistochemical expression of p21^<WAF1 Cip1> (p21) and TGF-β in rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO). p21, which inhibits cell proliferation, is induced by the wild type p53 tumor suppressor protein, and by TGF-β. Expression of p21 protein almost disappeared in tongue epithelial cells at 16 weeks after 4NQO administration, while p21 showed overexpression at 24 weeks. TGF-β was found in small amounts at 16 weeks and was expressed strongly at 24 weeks after administration of 4NQ0. These results suggest that the overexpression of p21 at 24 weeks may be induced by TGF-β. Our co-worker previously found that a p53 mutation occurred in the tongue epithelium at 16 weeks using this same model.
大阪歯科学会の論文
2008-03-25