10 4-nitroquinoline 1-oxide誘発ラット舌癌由来培養細胞モデルに対する微粒子二酸化チタンの光触媒効果(第496回大阪歯科学会例会)

概要

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We investigated the effect of photocatalytic reactions of titanium dioxide finepowder on rat tongue carcinoma cells induced by 4-nitroquinoline 1-oxide. Three types of titanium dioxide finepowder, anatase type ST-41, rutile type TP-3 and mixed type P-25, were added separately to culture fluid and were cultured for 48 hours. Each mixture was then exposed to 254 nm ultraviolet light. The cell survival rate was decreased in the cells cultured with any type of titanium dioxide finepowder, and the decrease was marked in the cells cultured with ST-41. Furthermore, the cell survival rate was decreased in correlation with irradiation time and concentration in the ST-41 group. We found an apoptosis ladder pattern which suggests that the apoptosis was concerned with the mechanism of cultured cell kill. These findings indicate that the photocatalytic reactions of ST-41 titanium dioxide finepowder may develop a new modality for cancer treatment.
大阪歯科学会の論文
2005-03-25