Dynamical Equation Approach to Protein Design
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概要
- 論文の詳細を見る
A new approach to protein design is proposed. Our dynamical equation approach is based on the criterion by Kurosky and Deutsch^<1), 2)>, with which the probability of a target structure in a conformation space is maximized at low but finite temperature. The key feature of the proposed approach is soft spin representation of monomer variables that leads to the "design equation".<3)> The advantage of the present approach is its parallel evolution of the monomer sequence variables and the resulting rapid convergence. We review the recent development of design schemes, implement numerical simulations by the design equation for the generalized HP model, <24), 26), 27)> and compare the performance with an algorithm based on the simulated annealing in sequence space.
- 理論物理学刊行会の論文
- 2000-04-28
著者
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時田 恵一郎
大阪大学サイバーメディアセンター
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時田 恵一郎
大阪大学サイバーメディアセンター、院理、院生命機能
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Matsuzaki K
Institute For Materials Research Tohoku University
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Kikuchi M
Tohoku Univ. Sendai Jpn
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Kikuchi Masae
The Research Institute For Iron Steel And Other Metals Tohoku University
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Kikuchi Masae
Institute For Material Research Tohoku University
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TOKITA Kei
Condensed Matter Theory Group, Graduate School of Science, Osaka University
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KIKUCHI Macoto
Condensed Matter Theory Group, Graduate School of Science, Osaka University
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IBA Yukito
The Institute of Statistical Mathematics
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Moroishi K
Hoya Corp. Tokyo Jpn
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Iba Y
The Institute Of Statistical Mathematics
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Moroishi Keiji
Institute For Materials Research
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TOKITA Kei
Department of Pure and Applied Science, College of Arts and Sciences University of Tokyo
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