<原著>Porphyromonas gingivalisとPropionibacterium acnesおよびP. avidumとの共凝集について

概要

論文の詳細を見る
Porphyromonas gingivalis coaggregation with Propionibacterium acnes and P. avidum was observed. These coaggregations were inhibited with L-arginine, L-lysine, L-cysteine and L-histidine. Heat- and proteinase K-treatment experiments indicated that cell surface heat labile-protein factors of P. gingivalis may adhere to the cell surface of heat-stable protein factors of P. acnes and P. avidum. Both P. gingivalis cells and vesicles promoted the coaggregation of P. acnes to the partner cell with which native P. acnes cells do not ordinarily coaggregate. It was confirmed that supernatants containing menadione like substances of P. acnes and P. avidum stimulated the growth of P. gingivalis in vitro, suggesting that these coaggregations play an important role in the growth of P. gingivalis in subgingival biofilms and in the progress of periodontal disease.
北海道医療大学の論文
2002-12-31