口腔内偏性嫌気性糖非分解性細菌Eubacteriumその意義と展望

概要

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Historically, it has been suggested for a long time that there are so many uncultured, undescribed and unknown bacterial species including VNC (viable but non-cultivable) in the human oral cavity, especially infectious lesions such as periodontal pockets. All these strains are asaccharolytic anaerobic gram-positive rods, and have been proven to be difficult to culture and unreactive in the conventional biochemical tests. The molecular systematic techniques including 16S rRNA gene sequencing analysis and DNA-DNA hybridization method have demonstrated that they are mainly Eubacterium and/or the related bacteria with Eubacterium, phylogenetically. And recently, many novel bacterial genera and species, such as genus Slackia, Eggerthella, Cryptobacterium and Mogibacterium, have been proposed on the basis of phylogenetic data for these bacterial strains. A complete description of the microbial flora associated with oral infections lead to the potential benefits for the elucidation of disease causation and also the development of novel diagnostic tools. In this paper, we summarize the recent knowledge of these bacteria species, and also discuss the etiologic roles of these bacteria in human oral infections.
北海道医療大学の論文
2005-12-30