<予防および治療>ラット新生児培養心筋細胞におけるtaurineの心肥大抑制作用

概要

論文の詳細を見る
The cardiac hypertrophy in the M strain of stroke-prone spontaneously hypertensive rats is regressed by taurine. To examine whether taurine suppresses cardiac hypertrophy without the influence of hemodynamic factors, its effect on the cardiac hypertrophy induced by noradrenaline (NA) was investigated in cultured cardiac myocytes. Primary cultures of cardiac myocytes were prepared from ventricles of neonatal Sprague-Dawley rats by the method of Simpson et al. Cardiac myocyte hypertrophy was determined by [^<14>C] phenylalanine (Phe) uptake into the cells. Two days after the additions of 2 μM NA, [^<14>C] Phe uptake was increased about 1.5-1.7 fold. This hypertrophic effect of 2μM NA was significantly suppressed by 2 μM prazosin and slightly by 2μM propranolol. Taurine suppressed the increase of [^<14>C] Phe uptake by 2μM NA in a dose-dependent manner, but β-alanine and glycine, which were used as an analogue of taurine, also had similar effect. These results sugest that the suppression of cardiac myocyte hypertrophy by taurine is a non-specific reaction.
近畿大学の論文
1989-12-30