TaurineのNa利尿作用 : 正常血圧者と本態性高血圧症患者との比較(B 臨床的研究)

概要

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In order to clarify the effect of taurine on the renal excretion of water and sodium, taurine (1g/20ml) was injected into the peripheral vein of 9 healthy volunteers and 21 patients with essential hypertension (12 cases were WHO I and 9 cases were WHO II). Urinary volume, urinary sodium excretion, urinary kallikrein activity, plasma renin activity and plasma aldosterone concentration were measured before and 30 and 60 minutes after injection of taurine. Urinary volume increased significantly 30 minutes after injection and urinary sodium excretion also increased significantly 30 and 60 minutes after injection in volunteers. This natriuretic effect of taurine was decreased in patients with essential hypertension along with the progress of the stage. Urinary kallikrein activity increased significantly 30 and 60 minutes after injection in volunteers, but did not increase significantly in patients with essential hypertension. Plasma renin activity and plasma aldosterone concentration decreased although not significantly. These findings suggest that taurine has natriuretic effect in which the kallikrein kinin system may play an important role. It is likely that poor natriuretic effect of taurine in this study may be due to the depression of kallikreinkinin system in essential hypertension.
近畿大学の論文
1984-12-25