M strain of stroke-prone spontaneously hypertensive rat(M-SHRSP)の高血圧発症維持機構における尿ナトリウム, taurine, kallikreinの意義について

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The purpose of this study is to determine how the urinary taurine (UTau) and the urinary kallikrein activity (UKal) which are the depressor system participate in the regulation of high blood pressure (BP) in the different stages of the development of M-SHRSP. Seven M-SHRSP and 8 Wistar Kyoto (WK) male rats were subjected to the experiment during 5 to 12 weeks (wk) of age. Body weight (BW), food intake (FI), water intake (WI) and the urine volume were measured every week by using a metabolic cage. Tissue taurine contents in the liver, brain and heart were measured at the age of 13 wk in both groups. UTau and UKal were measured by the fluorogenic method, UNaV, UKV and UClV by flame photometer and BP by the tail cuff method. In M-SHRSP BP was 170 mmHg at the age of 7 wk, increasing to 250 mmHg at 12 wk. There was no significant difference of FI, WI and urinary creatinine excretion between the two groups. UNaV, UKV and UClV were lower in M-SHRSP than WKY during the stages from 6 to 12 wk of age. The tendencies for BW to increase and for urine volume to decrease were observed in M-SHRSP when compared with WKY until 9 wk. UTau and UKal were higher in M-SHRSP than WKY during the stages from 6 to 9 wk of age. These values were lower in M-SHRSP than WKY after 10 wk. Taurine contents in the liver and the brain of M-SHRSP significantly decreased while the content in the heart did not, compared with WKY at the age of 13 wk. These findings suggest that taurine may regulate the kallikrein-kinin (K-K) system in M-SHRSP so as to promote the excretion of urinary sodium and to prevent the elevation of BP until 9 wk of age, and also that the K-K system may be attenuated by the decline of taurine synthesis from 10 to 12 wk.
近畿大学の論文
1987-12-30

M strain of stroke-prone spontaneously hypertensive rat(M-SHRSP)の高血圧発症維持機構における尿ナトリウム, taurine, kallikreinの意義について

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