本態性高血圧症における降圧剤治療と心拍出量の関係(B 臨床的研究)

概要

論文の詳細を見る
In order to evaluate the influence of anti-hypertensive drug treatment in the relation between hemodynamics and hypertension, cardiac output was measured before and after anti-hypertensive drug treatment by using four types of drugs for 6.1 months on the average in 72 out-patients with essential hypertension. The drug was divided into four groups ; Group I is β-blockers, Group II diuretics, Group III adrenergic blocking agents and Group IV Ca-antagonist (Nifedipine). The results are as follows. 1. After the treatment, cardiac output decreased significantly in Groups I, II, and III, while increased in Group IV. Systemic vascular resistance increased in the former and decreased in the latter. 2. In Groups I , II and III, the severity of hypertension and the duration of treatment were not related to the changes of hemodynamics by the treatment. 3. The decrease in cardiac output and heart rate after the treatment remained slight after the treatment of the β-blocker with an action of intrinsic sympathetic stimulation as compared to the other β-blocker groups. Venous pressure decreased significantly by only type 3 β-blocker according to Fitzgerald's classification. Thus, it is strongly suggested that augmentation of blood flow plays an important role in maintaining high blood pressure in essential hypertension irrespective of the stages of hypertension.
近畿大学の論文
1982-12-31