<基礎的研究発生病理>M-SHRSPとWKYの腎糸球体α_1受容体の比較

概要

論文の詳細を見る
We examined the α_1-adrenoceptor of isolated renal glomeruli in hypertensive M-SHRSP and normotensive WKY by the radioligand binding assay. The α_1-adrenoceptor was measured by using [^3H]bunazosin. There were two different types of α_1-adrenoceptors in WKY, one with high affinity and low binding capacity, and one with low affinity and high binding capacity. On the other hand, the M-SHRSP had only the α_1-adrenoceptor with a high affinity and low binding capacity. These results suggest that the α_1-adrenoceptor in glomeruli plays an important role in the development of hypertension.
近畿大学の論文
1989-12-30